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Symbol
Name
ID 		Col4a4
collagen, type IV, alpha 4
MGI:104687
Phenotype annotations related to renal/urinary system
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Hematuria
Proteinuria
Glomerular basement membrane lamellation
Thickened glomerular basement membrane
Thin glomerular basement membrane
Nephritis
Nephrotic syndrome
Renal insufficiency
Stage 5 chronic kidney disease
Disease(s) Associated with COL4A4
autosomal recessive Alport syndrome
benign familial hematuria

Mouse Phenotypes
enlarged urinary bladder
decreased urine potassium level
decreased urine sodium level
increased urine protein level
albuminuria
hematuria
leukocyturia
kidney inflammation
tubulointerstitial nephritis
abnormal kidney morphology
abnormal kidney cortex morphology
abnormal podocyte foot process morphology
podocyte foot process effacement
podocyte hypertrophy
abnormal renal glomerulus basement membrane morphology
increased renal glomerulus basement membrane thickness
abnormal renal glomerulus morphology
expanded mesangial matrix
glomerulosclerosis
glomerular crescent
renal glomerular synechia
abnormal kidney interstitium morphology
renal interstitial fibrosis
small kidney
renal tubule atrophy
dilated renal tubule
renal cast
pale kidney
decreased creatinine clearance
kidney failure
polyuria
Availability Mouse Genotype
Col4a4bwk/Col4a4bwk ! ! ! !
Col4a4em1(IMPC)H/Col4a4em1(IMPC)H
Col4a4m1Btlr/Col4a4m1Btlr
Col4a4m1H/Col4a4m1H ! ! ! ! ! ! ! ! ! !
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory